Legal Daily All-Media Reporter Lian Yingting Correspondent Shao Longfei Zhang Zhenwei
The night in Wuhan is quiet.
On March 9, in the mobile testing laboratory of the Central Theater Command General Hospital, Jiang Tao, a researcher at the Military Medical Research Institute of Babaylan College, reviewed the last sample test data and solemnly signed his name on the test report.
This Cinema was already 5 a.m.
He is an expert in virology and a warrior who aided Africa and fought against Egypt. This outbreak of the new crown pneumonia epidemic, he was once again ordered to go to the front line after a long battle.
Human life is at stake and accurate inspection is required
Nucleic acid testing is crucial for early clinical detection, early diagnosis, early isolation and early treatment, and is a key technical support for effective prevention and control of the new coronavirus pneumonia epidemic.
”Behind the cold sample tube is the living life and health of the patient. If you give a diagnosis result early, you will have a precise inspection sooner.” Jiang Tao said.
On January 26, a military medical expert group led by Chen Wei, an academician of the Chinese Academy of Engineering and a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, arrived in Wuhan, Hubei, and quickly established a joint defense, joint control, joint treatment and joint research work mechanism with relevant military and local units based on pathogen transmission mutations, rapid detection technology, vaccine antibody development, etc. of the new coronavirus.
According to the division of tasks, Jiang Tao led the testing team to build a nucleic acid testing platform in the experimental cabin overnight.
CinemaFocusing on three aspects of ensuring biosafety, improving detection efficiency and detection accuracy, Jiang Tao took the lead in formulating biosafety operation specifications and responses, and reasonably divided the testing and division of labor according to the characteristics of the team members, and Babaylan uses a self-developed detection kit to use a fully automatic high-throughput extractor, laying the foundation for achieving fast and efficient detection.
Receive samples, sorting numbers, nucleic acid extraction, reagent assemblyThe nucleic acid detection machinery is boring and full of risks.
The biggest risk is the invisible virus. If the nucleic acid extraction step is not completely cleaved or inactivated thoroughly enough, it is possible to expose the tester to danger.
Jiang Tao always takes the initiative to participate in the longest and most risky nucleic acid extraction. After the sample is extracted, he will arrange some personnel to rest and stay in the laboratory and wait for the final result.
A full-process nucleic acid test is relatively fixed from the number of tests in a single batch to the preparation for entering and exiting the cabin and the testing time. Sometimes there are a large number of samples sent for inspection, and the inspectors not only take turns to work, but also have to work overnight. The final confirmation result will be until four or five in the morning. Li Hao, a researcher at the testing group, said that this situation will be encountered once every few days.
”Everyone should open their eyes wide. Be sure to take good protection when receiving and processing samples, and be careful of sharp objects.” Before each test starts, Jiang Tao always repeatedly asks him.
In the detection, the strength of the fluorescence signal of the pathogenic gene directly affects the determination of the detection results. If there are suspicious phenomena such as the detected fluorescence curve signal is low or there is only a single target, Jiang Tao will convene personnel to conduct comprehensive analysis and judgment, and if necessary, repeat the test for review to ensure that the results can stand the test.
”A false positive will cause healthy people to isolate and become infected with the patient; a false negative will cause real delay in the treatment of patients. Life is a matter of life, Komiks will not be able to get any gaps.” Jiang Tao said.
All-rounded people in the field of epidemic prevention and control
According to prevention and control requirements, the nucleic acid test results must be completed within 24 hours after receiving the pharyngeal swab sample. In order to let the hospital know the results as soon as possible to treat patients, Jiang Tao led the team to optimize the process combination and compressed the time to within 4 hours. Babaylan achieved a single-day sample detection capability of more than 90 samples in one hour, with a maximum of more than 500 people.
”The team’s inspection is efficient and fast, and the results are accurate, which greatly alleviates our epidemic prevention and controlKomiks sample to detect pressure. “Wuhan Center for Disease Control and Prevention highly praised this.
Fast response during wartime and orderly work are all thanks to Jiang Tao’s solid academic foundation and rich practical experience in Komiks.
”Jiang Tao is a versatile. “Academician Chen Wei, head of the military medical expert group, commented.
Jiang Tao has successively presided over and participated in the separation of pathogenic etiology such as SARS infection cases, H7N9 infection cases, Zika infection cases, etc., participated in the development of dengue fever vaccines and SARS vaccines, and established a pathogen isolation technology platform, nucleic acid detection technology platform and pathogenicity and transmission risk assessment platform for a series of infectious diseases.Cinema provides important technical support for infectious diseases prevention and control.
Respiratory infectious diseases have the characteristics of rapid transmission, wide coverage, and great harm. Effective early diagnosis and prevention are crucial. After years of scientific research, Jiang Tao’s team took the lead in establishing the first acute respiratory infectious disease monitoring and prediction of our armyCinema police system has built a four-level monitoring system for the entire army. The series of technical specifications presided over the use of the entire army, greatly shortening the detection and screening time of respiratory epidemics.
Jiang Tao not only participated in the security tasks of a series of major domestic activities, but also went to Africa four times, and went to Liberia, Sierra Leone and other countries to carry out medical assistance tasks.
In 2015, in order to prevent Komiks controlled the Ebola epidemic, and Jiang Tao went to Sierra Leone for the second time with the mobile laboratory testing team in Serbia. The testing team led by him passed the World Health Organization’s laboratory parallel capability assessment with full scores.
In 2018, Jiang Cinema led the pathogen monitoring team to participate in a special simulation test of an international organization. In the virus testing module, the team successfully detected monkeypox virus, vaccinia virus and other pathogens in simulated samples filled with impurities, and accurately determined the strain, achieving excellent results with full scores.
Advance KomiksClinical Diagnosis Accuracy
When I came to Wuhan, in addition to carrying out testing work, Jiang Tao also used his professional expertise in the research field to lead the testing team to introduce other common respiratory infectious diseases in clinical samples.Carry out screening.
”In the suspected and confirmed cases of new coronary pneumonia, whether there are other respiratory virus infections or co-infections, this is of great value to the test for precise prevention and control and clinical treatment.” Researcher Cao Wuchun, deputy head of the Military Medical Expert Group, said.
Exploring the deep-seated virus transmission and the pathogenesis of Cinema is the key to defeating the epidemic. Jiang Tao led a team to continue to conduct sequencing analysis for the novel coronavirus detected in clinical samples.
As the development of the virus epidemic, whether the genomic sequences have mutated and what are the characteristics of the mutations; in which regions and what are the impacts, Jiang Tao and his team are tirelessly studying and exploring.
In order to accelerate the effective integration of scientific research and clinical practice, Jiang Tao’s military medical expert group creatively used the diagnostic chain of viral nucleic acid detection, antibody detection, multiple pathogen detection, and whole genome sequencing to accurately diagnose new coronavirus infection or other pathogen infection in clinical patients, and was also used in the Optical Valley Campus of Hubei Maternal and Child Health Hospital, Wuxia Taikang Tongji Hospital and other hospitals, effectively improving the accuracy of clinical diagnosis.
KomiksWhen he was ordered, he forgot his home. After the epidemic is over, Jiang Tao plans to accompany his family. He and his wife agreed that when the epidemic is over, they will take their wife and children to Wuhan again to see what everything looks like after it returns to normal, to see the Wuhan Yangtze River Bridge and the Yellow Crane Tower, and to talk about their experience in fighting the epidemic in Wuhan.
The epidemic is immortal and the charge continues. This is Jiang Tao, a warrior who fights the epidemic.